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John Randolph, also known as John Randolph of Roanoke, was the son of Frances Bland Randolph and John Randolph of Matoax in Chesterfield County, Virginia. He was the stepson of St. George Tucker; godfather of John Randolph Bryan. He was born in 1773 in Cawsons, Prince George County, Virginia. Randolph studied at the College of New Jersey (now Princeton University) and Columbia College in New York City. He was renowned for his oratory skills. He served several terms in the US House of Representatives and in the Senate from 1825 until 1827. He was also appointed as the United States Minister to Russia by President Andrew Jackson. He is believed to have suffered from symptoms of tuberculosis since his childhood which may have prevented his going through puberty. He never married. He died of tuberculosis in Philadelphia on May 24, 1833.

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